| | IT and Hardware and Services | Salford | £1B |
| | Link 3: IT Hardware and Services | Salford | £1B |
| | SARS-CoV-2 Antigen Rapid Qualitative Test Kits | London | £875M |
| | Waste Management Services | West Malling | £750M |
| | Planned and Responsive Repairs and Maintenance Contractor Framework | Newcastle upon Tyne | £500M |
| | Residential Care Home Services (Learning Disability, Physical Disability & Mental Health), Supported Living Services and Care… | Maidstone | £434M |
| | Sterile Services and Endoscopy Decontamination Facility Solutions | Chester | £375M |
| | Supported Living Framework | Chelmsford | £345M |
| | Development Partner for Hengrove Park | Bristol | £290M |
| | North East Prisons | Darlington | £240M |
| | Artificial Limb Components and Associated Products | Normanton | £240M |
| | Framework for Beds, Mattresses and Wheelchairs Both Services and Products, Continence Home Delivery Services Plus Managed… | Salford | £240M |
| | Covid-19 Testing Site Facilities Management | London | £221M |
| | Community Home Care Service | Leeds | £201M |
| | Document Storage, Records Management and Integrated Solutions | Salford | £200M |
| | West Midlands Regional Supported Accommodation Flexible 2021 (16 to 21 Year Olds) | Stafford | £175M |
| | Highway Maintenance, Design, Construction and Other Services — CPU 455 | Oxford | £166M |
| | Learning Disability Community Support Services | Leeds | £165M |
| | Lower Thames Crossing - Integration Partner | Bedford | £162M |
| | Lower Thames Crossing — Integration Partner | Bedford | £162M |
| | SARS-CoV-2 Antigen Rapid Qualitative Test Kits | London | £152M |
| | National Healthcare Uniforms | Sheffield | £125M |
| | DfE ApprenticeshipsNI 2021 Programme (Apps21) | Belfast | £122M |
| | Planned Fire Safety and Fire Prevention Works Programme | Croydon | £120M |
| | TfL 93871 RideLondon | London | £112M |
| | Structural Heart, Perfusion and Ventricular Assist Devices Including Consumables | London | £108M |
| | Kitchens Framework | Newcastle upon Tyne | £100M |
| | London Borough of Lambeth Block Cleaning and Concierge Services | London | £99M |
| | YHA Coated Materials Ready Mixed Concrete & Aggregates 2021-25 | Leeds | £90M |
| | TfGM's Professional Services Framework | Manchester | £88M |
| | Provider Panel for Day Services | Durham | £87M |
| | Structural Heart Valves, Perfusion and Ventricular Assist Devices and Consumables | London | £85M |
| | Domiciliary Support Service 2020 Lot 1: General Domiciliary Support in Leicester City | Leicester | £83M |
| | Decontaminated Waste Asbestos - Innovation Partnership | Cumbria | £80M |
| | Intrusive Surveys Framework Restoration and Renewal Programme | London | £80M |
| | Intrusive Surveys Framework Restoration & Renewal Programme | London | £80M |
| | Office Furniture Solutions and Associated Services | Wakefield | £75M |
| | Education Materials | Paisley | £70M |
| | Independent Living Support Within the Vale of Glamorgan | Barry | £64M |
| | NEYTH Lot-Former Harrogate Police Training College-Harrogate | City Walk | £64M |
| | Powered and Non-Powered Wheelchairs, Specialist Seating and Associated Repairs | London | £60M |
| | School and Academies Furniture and Associated Supplies and Services Framework | Salford | £60M |
| | Workforce Transformation Solutions | Chester | £60M |
| | Central Venous Catheters and Associated Products | London | £57M |
| | Scotland's Baby Box 2022 | Edinburgh | £56M |
| | Scotland's Baby Box 2022 | Edinburgh | £56M |
| | CCTV and Access Solutions | West Malling | £50M |
| | NUN - Modern Methods of Construction, Architect and Employer's Agent Framework | Warwickshire | £50M |
| | NUN - Modern Methods of Construction, Architect and Employer’s Agent Framework | Nuneaton | £50M |
| | Health Research Programme Consortia (RPCS): Filling the Gaps in Evidence: Building Stronger and More Resilient Health… | East Kilbride | £46M |
| | Grounds Maintenance and Tree Services | London | £44M |
| | ICT Support Service | London | £44M |
| | ICT Support Services | London | £44M |
| | Buckinghamshire Integrated Community Equipment Service | Aylesbury | £44M |
| | Central Specialist DevOps Services | Croydon | £40M |
| | Construction Contractor Framework for BCUHB & WAST | None | £40M |
| | Kirklees Integrated Sexual Health Service | Huddersfield | £39M |
| | Kirklees Integrated Sexual Health Services | Huddersfield | £39M |
| | Design and Build of Police Patrol Craft | Bristol | £36M |
| | NCDS Support Service | London | £32M |
| | Repairs and Voids Refurbishment of Council Housing Stock Framework | London | £32M |
| | Test & Trace: Schools Mass Wholesale Distribution | London | £32M |
| | Direct Payment Support Services Framework | Nottingham | £30M |
| | West Yorkshire Patient Transport Services | Halifax | £30M |
| | Southampton Improving Access to Psychological Therapies (IAPT) Service | Southampton | £28M |
| | Skills Training in the Nuclear Sector — DPS for Skills Providers and Training Provision, Skills for… | Chester | £27M |
| | Training in Coding and Digital Skills — DPS for Skills Providers and Training Provision, Skills for… | Chester | £27M |
| | Care and Support for Extra Care Housing | Ellesmere Port | £25M |
| | Design and Build of Police Patrol Craft | Bristol | £25M |
| | Services to Recruit International Foundation Students for the University of Birmingham | Birmingham | £25M |
| | Shakespeare Street Main Contractor | Nottingham | £25M |
| | Voice & Data Telecommunications Framework | Derby | £25M |
| | Standard Length Examination Gloves, Nitrile | Belfast | £21M |
| | IRM20/7530 - The Supply of Tyres | Telford | £21M |
| | Shakespeare Street Main Contractor | Nottingham | £21M |
| | Design and Construct New Dunclug College, Ballymena — Ref MA16-000D14 | Belfast | £20M |
| | Air Purification, Decontamination and Isolation Systems Dynamic Purchasing System | Chester | £20M |
| | Energy Efficiency Partner - REFIT Programme | London | £20M |
| | Metal (Non-Coal) Mines Delivery Programme Until 2025/26 | Cardiff | £20M |
| | Workwear Garments | Bristol | £20M |
| | Major Works Integrated Consultant Team (ICT) Frameworks | Belfast | £18M |
| | Plutonium Disposition Mox Services Framework Three Lots LOT 1 Mox Plant Design Services LOT 2 Mox… | Cumbria | £18M |
| | Trade Materials and Associated Services | Stirling | £17M |
| | Enablement at Home Floating Support Services | Hatfield | £16M |
| | Voice & Data Telecommunications Framework | Derby | £15M |
| | Housing Related Support Services (HRS): Multi Lot( ASC-2021-003) | Wembley | £15M |
| | Coated Roadstone | Lochgilphead | £15M |
| | West Yorkshire Traffic Signal Maintenance | Leeds | £15M |
| | Delivery Partner for Programme CASTLE | Liverpool | £15M |
| | Phalanx In-Service Support | Bristol | £15M |
| | Cadent Gas Property Main Works Contractors | Coventry | £15M |
| | Digitising and Remote Sensing Services | London | £15M |
| | Technical Third Party Support (TTPS) for the Net-Zero Innovation Portfolio (NZIP) | London | £15M |
| | Troughing and Minor Line Side Civils Works | Pontypridd | £15M |
| | WSCC - SA - Ash Dieback (ADB) Tree Felling Works Along the Highway Network and Other… | West Sussex | £14M |
| | Support of Portable Atmosphere Monitoring Systems (PAMS) | Bristol | £14M |
| | Clehonger Development | Leicester | £14M |
| | Supported Accommodation | Irvine | £14M |
| | Housing Maintenance | Bridgend | £13M |
| | TSSP/118 Scopic 2 | Bristol | £13M |