| | Medical Examination Gloves and Surgical Gloves | London | £6B |
| | Single Use PPE and Medical Protective Consumables | London | £5B |
| | Leisure Development Partner for the UK Leisure Framework 2022 | Denbigh | £2B |
| | Pathology Services | London | £2B |
| | Media Services | Liverpool | £1B |
| | MWCC - Surfacing Packages | Birmingham | £1B |
| | Strategic Energy and Asset Management Performance Framework (SEAM) | Newcastle upon Tyne | £750M |
| | SEC Responsive Repairs, Voids, Planned Works DPS | Sittingbourne | £500M |
| | Monklands Hospital Replacement Project | Bothwell | £350M |
| | Commissioning Debt Advice in England | London | £321M |
| | Covid-19 Home Testing Fulfilment Services | London | £269M |
| | Care Packages for Children's Continuing Care | London | £210M |
| | Document Storage, Records Management and Integrated Solutions | Salford Quays | £200M |
| | Finance Solutions | London | £200M |
| | Minor Building Works | Telford | £200M |
| | Enactment of MoJ's Extension Option for Shared Services With SSCL | London | £181M |
| | Modification Notice - Specialist Technical and Commercial Advisory Services for Rail and Other Transport Modes Framework… | London | £158M |
| | Lateral Flow Testing Devices | London | £144M |
| | Lateral Flow Testing Devices for the Detection of COVID-19 Viral Antigens | London | £144M |
| | Eastern Region Examination Structures | London | £135M |
| | Works to Utilities Building and Willow Yard, Kyloe House | Morpeth | £125M |
| | Anti-Infective (Infection Management and Cystic Fibrosis) Homecare Service | Bracknell | £112M |
| | South Cambridgeshire District Council - Repairs, Maintenance and Asset Services | Cambourne | £111M |
| | Lateral Flow Testing Devices for the Detection of COVID-19 Viral Antigens | London | £104M |
| | Public Realm Maintenance and Improvements | London | £90M |
| | Repair of Armoured Fighting Vehicles (AFV) Heavy Road Wheels | Shropshire | £81M |
| | Digital Partner | Nottinghamshire | £80M |
| | Minor Works Framework for Building Maintenance | Haverfordwest | £80M |
| | University of Nottingham - Digital Partner | Nottingham | £80M |
| | Abbott ID Now Continued Supply FY 21/22 | London | £78M |
| | Consultants Framework for NHG Development - Market Engagement Opportunity | London | £75M |
| | Modification Notice to COVID-19 Test Digital Platform | Leeds | £75M |
| | Evidence Fund | East Kilbride | £72M |
| | Residual Waste Treatment and Disposal 2021 - CPwN | Inverness | £66M |
| | Lateral Flow Testing Devices for the Detection of COVID-19 Viral Antigens | London | £62M |
| | NHS England and NHS Improvement (East) - Cambridgeshire Prisons, Claire Lodge SCH and Dental Services at… | Cambridge | £62M |
| | Microsoft Software Licences and Azure Services | Moor Row | £61M |
| | Combat Garments | Bristol | £56M |
| | Library Books, Educational Textbooks & Multimedia Supplies | Paisley | £56M |
| | Glasgow City Council Purchased Foster Care and Adult Placement Framework | Glasgow | £54M |
| | Custody and Investment Operations Outsourcing Services | Croydon | £53M |
| | Planned Maintenance and Minor Works Framework Call Offs | Stafford | £50M |
| | Lot 1a Neutral Vendor | Morden | £48M |
| | Regional Solar Framework | Bradford | £42M |
| | Ambient Food | London | £37M |
| | FA-LS Managed Services for Temporary Agency Resources - ESPO Ref 653F_19 (MSTAR3) Lot 1 - Managed… | Bedfordshire | £35M |
| | NHS Education With Medway NHS Foundation Trust | Leeds | £31M |
| | NHS Education With Medway NHS Foundation Trust | Leeds | £31M |
| | Leak Detection and Water Efficiency | Worthing | £30M |
| | EA Integrated Financial Management Information System Inc. HR/Payroll (The iFS Project) | Belfast | £29M |
| | Crime Survey for England and Wales | Newport | £29M |
| | Trastuzumab (Herceptin®) 600mg/5ml Solution for Injection | Edinburgh | £27M |
| | IT Peripherals 4th Generation | Glasgow | £25M |
| | Precast Concrete | Glasgow | £24M |
| | Waste Transfer Services | Suffolk | £24M |
| | Property Services - Domestic Heating - 05 | London | £24M |
| | FIT - Out Services - Bristol Hub | Liverpool | £24M |
| | Professional Services Framework Agreement | Irvine | £23M |
| | Central Heating Boiler Replacements and Associated Works | Leicester | £23M |
| | Framework for Planned Works to Domestic Properties | Cardiff | £23M |
| | Early Intervention and Prevention Pseudo Dynamic Purchasing System (DPS) | Peterborough | £21M |
| | Hard Facilities Management | Coventry | £21M |
| | Office Furniture | Leicester | £20M |
| | Council Housing Electrical Upgrade Programme Phase 2 | Sheffield | £20M |
| | BSH/HGW/Maintenance and Installation of Highway Electrical Assets | Bristol | £20M |
| | Habinteg Housing Response Maintenance Measured Term | Holywood | £20M |
| | Innovative Waste Solutions Dynamic Purchasing System | Chester | £20M |
| | IT Procurement Strategy Service and Renewal Management | London | £20M |
| | Maintenance and Installation of Highway Electrical Assets | Bristol | £20M |
| | Services-Framework-Group Mechanical, On-Site Services and Off-Site Fabrication | Warrington | £20M |
| | Shaft & Silo Process Cell & Waste Transfer System | Thurso | £20M |
| | Transport of Medicines From NHS Hospitals to Patients | London | £20M |
| | Transport of Medicines From NHS Hospital to Patients | London | £20M |
| | Waste Transfer Services | Ipswich | £20M |
| | Support to Phase 2 of RWM Plutonium Integrated Project | Didcot | £19M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £17M |
| | Pennywell Regeneration Project | Sunderland | £17M |
| | MTC for Combined Re-Roofing, Re-Rendering, External Wall Insulation and Solar Panel Installation | Irvine | £16M |
| | Dynamic Purchasing System for Passenger Transport Services | Morpeth | £16M |
| | NHS Education With Milton Keynes University Hospital | Leeds | £15M |
| | NHS Education With Milton Keynes University Hospital | Leeds | £15M |
| | Learning Disability Day Activities Framework (Spot Purchases) | London | £15M |
| | Shaft & Silo Process Cell & Waste Transfer System | Thurso | £15M |
| | Water Resource Accountability in Pakistan (WRAP) | East Kilbride | £15M |
| | Technical Third Party Support (TTPS) for the Net-Zero Innovation Portfolio (NZIP) | London | £14M |
| | Neutral Vendor for Temporary Labour | London | £14M |
| | Training Services | Aberdeen | £14M |
| | Cumbria Addictions Service — North | Carlisle | £14M |
| | EXTRACARE CHARITABLE TRUST - Contracts for Hard Facility Management | Reigate | £14M |
| | Fire Appliances (Type B Light Rescue) for Hampshire and Isle of Wight Fire and Rescue Service… | Winchester | £13M |
| | Installation of Failsafe Support System and Associated Works | Bury St Edmunds | £13M |
| | Temporary Power & HVAC | Birmingham | £13M |
| | Creation of Extended Berth Including Dredging | Portland | £12M |
| | CSI-ED-Alternative Learning Framework | Bristol | £12M |
| | Pension Administration Services | Northampton | £12M |
| | Whiteboard Markers | Wakefield | £12M |
| | DFAP/0024/022 Supply and Delivery of F35 (TRANSPARENCY NOTICE ONLY) | Bristol | £12M |
| | National Institute for Health Research (NIHR) Information Systems (IS | Westminster | £12M |
| | Commissioning Debt Advice in England | London | £12M |
| | Medway Make Ready Centre and EOC | Crawley | £12M |