| | NHS England - Increasing Capacity - Refresh | Leeds | £10B |
| | Retrofit Accelerator for Homes: Deep Retrofit of Domestic Properties | London | £10B |
| | Single Use PPE and Medical Protective Consumables | London | £5B |
| | Imaging, Radiotherapy, Endoscopy, Ancillary Devices and Related Goods & Services | London | £4B |
| | Prj_4859 - MoJ Constructor Services Framework | London | £2B |
| | Healthcare Services by NHS and Other Public Bodies (Including Clinical Services) | South Yorkshire | £2B |
| | Vehicle Lease, Fleet Management & Salary Sacrifice | Liverpool | £2B |
| | Residential and Nursing Care Homes DPS | Reigate | £2B |
| | Construction Consultancy Services 3 | Salford | £2B |
| | Low and Zero Carbon Technologies | Manchester | £1B |
| | Apprenticeships Commissioning Programme Wales Framework Agreement | Cardiff | £1B |
| | Major Building Works Contracts | London | £835M |
| | Pharmacy Homecare Services - Low and Mid Tech | Exeter | £521M |
| | Next Generation Operational Training | High Wycombe | £500M |
| | Buckinghamshire Integrated Community Equipment Service | Aylesbury | £350M |
| | Infusion Pumps Administration Sets and Associated Products | London | £332M |
| | OptiGene GenieHT Machines and Covid-19 RT-LAMP Test Kits | London | £323M |
| | Pharmacy Homecare Services - Low and Mid Tech - T20/ | Exeter | £278M |
| | M5 Junction 10 Improvements Scheme | Gloucester | £200M |
| | Low and Zero Carbon Technologies | Manchester | £195M |
| | AMIDS Private Sector Partner | Paisley | £150M |
| | Cambridgeshire County Council Design & Build Contractor Framework | Cambridge | £150M |
| | CHIC Compliance Audit Services Framework | Birmingham | £150M |
| | Local Bus Services and School Bus Services - Dynamic Purchasing System | Preston | £140M |
| | Future eGates - Future Opportunity | London | £132M |
| | Assessment Service Information Systems (ASIS | Blackpool | £124M |
| | Joint Waste Collection and Cleansing | Ashford | £112M |
| | Application & Enrolment BPO Service Agreement | London | £102M |
| | Acquisition, Design and Build Framework (ADB Framework) | London | £100M |
| | Employee Development Services | Sheffield | £100M |
| | Integrated Community Equipment Service | Norwich | £100M |
| | NHS NOE CPC - Employee Development Services | South Yorkshire | £100M |
| | Integrator Change Request ICR121F | Leeds | £99M |
| | Dungavel House Immigration Removal Centre | London | £96M |
| | Affordable Financial Services Products: No Interest Loan Scheme (NILS) and Innovative Affordable Finance Solutions | London | £90M |
| | LD Supported Living - HOWDAB Pt 2 | Oxford | £90M |
| | NHS England (Midlands) - HMP Birmingham - Healthcare Services | Rugeley | £89M |
| | NHS England (Midlands) HMP Birmingham - Healthcare Services | Rugeley | £89M |
| | Integrated Outbound Security Solution (ATRS, EDS C3 Cabin Baggage CT & CIP) | Manchester | £80M |
| | LA/VLA Analytical Services - Market Engagement | Seascale | £70M |
| | Brize Norton Support | High Wycombe | £68M |
| | Pharmacogenomics Informed Medications Management Service | Edinburgh | £66M |
| | Hull University Teaching Hospitals ~ Retails Food Service | Hull | £64M |
| | High Dependency (Lockable) Rehabilitation and Complex Care Rehabilitation for Patients With Learning Disabilities, Mental Health Issues… | Derby | £60M |
| | Lighthouse Schools Partnership ~ Cleaning | Portishead | £54M |
| | Command and Control System | Bridgend | £51M |
| | Design and Consultancy Services Framework | Newcastle upon Tyne | £50M |
| | Supported Living for Adults Transforming Care Project (TCP)– Round 2 | Norwich | £50M |
| | Swansea University | Swansea | £47M |
| | Swansea University | Swansea | £45M |
| | Belfast Harbour Film Studio - Phase 2 | Belfast | £44M |
| | Exolum-PS - F-35 - Dec 21-Jun 22 | Bristol | £43M |
| | Covid-19 Awareness Campaigns | Liverpool | £40M |
| | EKFB JV - FRC Works at Sheephouse Wood Bat Mitigation Structure (35,000m3) | Birmingham | £40M |
| | EOECPH: Medical Gases | Cambridge | £40M |
| | Framework Roads Related Maintenance Works | Paisley | £40M |
| | Hull University Teaching Hospitals ~ Retails Food Service | Hull | £40M |
| | Medical Gases | Fulbourn | £40M |
| | Systems Delivery and Integration Services Framework | London | £40M |
| | Surgical Dressings and Miscellaneous Products | Belfast | £38M |
| | Leicester Specialist Substance Misuse Service | Leicester | £34M |
| | Urgent Treatment Centres - Bromley | London | £32M |
| | Urgent Treatment Centres - Bromley - Prior Information Notice | London | £32M |
| | Croydon Intermediate Care Bed Service | London | £32M |
| | LD Supported Living - HOWDAB Pt 2 | Oxford | £30M |
| | CHIC Conveyancing Search Framework | Birmingham | £30M |
| | Cornwall Council Framework for the Supply, Installation, Operation and Maintenance of Electric Vehicle Charge Points | Truro | £30M |
| | National for Fixed Fee Procurement Project Delivery Services | Chester | £30M |
| | Northern Estate Architectural and Lead Design Services | London | £30M |
| | North Halifax Transformation Programme | Halifax | £30M |
| | Fabric Building, Yeoman Lane, Leicester LE1 1AD | Nottinghamshire | £30M |
| | Procurement of Aircraft 701575443 | Bristol | £29M |
| | Sewer Jetting, Wet Well Cleaning and Sewer Surveys (With Simple and Standard Coded Reports) | Huntingdon | £28M |
| | Estates and Facilities Framework | Wellingborough | £28M |
| | External Assistance to Director Assurance Delivery Partner (DADP) Using the CCS Management Consultancy Services Framework RM3745… | Glasgow | £28M |
| | Open Access Sexual Health Services Are Statutory in Nature and Local Authorities Are Required to Provide… | Reigate | £27M |
| | Reablement and Support at Home Services - Strategic Lead Provider for Stevenage and St Albans | Hertfordshire | £26M |
| | CHIC Compliance Audit Services Framework | Birmingham | £25M |
| | Dawlish to Holcombe Cliff Resilience Works | London | £25M |
| | Design and Build of a 5G Network in Basing View, Basingstoke | Basingstoke | £25M |
| | Kitchen and Bathroom Refurbishments & Associated Works - Planned & Reactive | Leicester | £25M |
| | Franking Machines & Consumables | Stirling | £24M |
| | Future Corporate Systems | Belfast | £23M |
| | Ardrossan North Shore Enabling Works | Irvine | £23M |
| | Election and Electoral Registration Print | Newcastle upon Tyne | £20M |
| | Election and Electoral Registration Printing | Newcastle upon Tyne | £20M |
| | Liquid Fuels | Beverley | £20M |
| | NHS.UK App | Leeds | £20M |
| | Pennywell Regeneration Programme | Sunderland | £19M |
| | BSH/HGW/ the Supply, Installation and Maintenance of Equipment and Infrastructure for the Control and Management of… | Bristol | £18M |
| | BSH/HGW/Traffic Signals Maintenance, Supply & Installation | Bristol | £18M |
| | FMRP - Flask Maintenance Facility Upgrade Project | Seascale | £18M |
| | Managed Learning Services | Leeds | £18M |
| | Pennywell Regeneration Project | Sunderland | £18M |
| | Technical Survey and Testing Contracts - Topographical | Birmingham | £18M |
| | APMS Services for Lot 1 St Neots Health Centre and Walk in Centre in Cambridgeshire, Lot… | Cambridge | £18M |
| | Construction of Social and Affordable Housing at Ballinderry Road, Lisburn | Londonderry | £16M |
| | Kent Strategic Modelling Custodianship | Maidstone | £16M |
| | Cleaning Materials and Equipment | West Sussex | £15M |
| | Pest Control Products and Services | Leicester | £15M |