Fluorescence-detected Taylor Dispersion Analyser

Location

Description

Supply and installation of the following equipment, along with associated services: • Fida Neo System UV • Fida Neo 480 Detector • Kinetics Software Module • Installation, training and freight • Two-year Full Coverage Service Agreement The system is a fluorescence-based capillary flow instrument for accurate quantification of particle size (hydrodynamic radius), fluorescence intensity and fluorescence ratiometric emission monitoring.

Award Detail

CPV Codes

• None found

Legal Justification

The FidaNeo system provides capability for analysing biomolecular interactions directly in solution using proprietary FIDA technology, enabling measurement of binding affinity and molecular size changes in complex matrices such as serum or lipid nanodisc systems. No instruments other than the Fida Neo could be identified that are capable of making the required measurements. No other instrument researched was capable of measuring the sub-nanometer size changes associated with protein conformational change (e.g. upon a drug binding to its target protein), nor did any other instrument researched provide the complementary readouts of fluorescence intensity required for quantifying particle concentration, quantifying fluorescent labelling efficiency, and measuring fluorescence quenching) and fluorescence ratiometric emission monitoring (required for measuring protein-drug binding).

Other Information

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