| | SEC Zero Carbon Framework | Surrey | £5B |
| | SOL - Constructing West Midlands 2 (Construction Framework) | Solihull | £2B |
| | Modular Building | Salford | £2B |
| | Apprenticeship Training and End Point Assessment Services | Salisbury | £1B |
| | Cambridgeshire County Council Highway Services | Cambridge | £900M |
| | Digital Capability for Health | Liverpool | £800M |
| | NHS Framework for the Midlands and East, Branded Medicines – Tranche B Plus Cytokine Modulators and… | Runcorn | £644M |
| | Utilities (Energy Consultancies and LED Lighting Solutions) | Birmingham | £510M |
| | Multi-Disciplinary Consultancy Services (MDC1) - CPC and London & SE | Uxbridge | £500M |
| | Campaign Solutions 2 | Liverpool | £490M |
| | Global Networks Programme | Warwick | £450M |
| | Older Adults Residential and Nursing Care Services | Carlisle | £450M |
| | North East Essex Integrated Community Services | Colchester | £440M |
| | Neurology, Spine Surgery Goods & Services | Birmingham | £435M |
| | Traineeships Reforms and Expansion Programme | Coventry | £380M |
| | Tower 2 — Minimally Invasive Surgery | London | £320M |
| | Precast Slab Track System | Birmingham | £260M |
| | Multi Temperature Food Solutions | London | £240M |
| | Veterinary Delivery Partnership — Livestock Testing Services in England and Wales | London | £205M |
| | UK Deployable Food | Bristol | £175M |
| | Scape National Consultancy Framework - Scotland | Edinburgh | £150M |
| | Highway Maintenance Services | Taunton | £138M |
| | Endourology Products and Accessories | London | £120M |
| | Internal and External Materials (Adapted Bathrooms) | Alfreton | £117M |
| | A9 Dualling: Tomatin to Moy | Glasgow | £115M |
| | The Supply and Delivery of Chemicals | Glasgow | £115M |
| | Personal Protective Equipment (PPE) | Liverpool | £106M |
| | Internal and External Materials (Windows and Doors) | Alfreton | £106M |
| | Outsourced ICT Framework Agreement | Salford | £100M |
| | Fencing, Vegetation, Pest and Disease Management, Ecology and Stonewalling Services | London | £98M |
| | Forum, King's Quarter, Gloucester | Gloucester | £94M |
| | ILW Retrieval & Processing Framework | Oldbury Technical Centre | £90M |
| | DPS for Domiciliary Care Services in Powys | Llandrindod Wells | £86M |
| | Digital Capability Framework | London | £75M |
| | Highways Asset Management and Associated Works Framework 2021 | Bristol | £70M |
| | En:Procure Framework for Installation, Servicing, Maintenance and Repair Works | Sheffield | £65M |
| | Managed Service Provider for Temporary Staff | Huddersfield | £64M |
| | National Tutoring Programme Phase 2 | London | £62M |
| | National Tutoring Programme Phase 2 (NTP P2) | London | £62M |
| | Cleaning, Catering (Hostess) and Portering Services | Norwich | £60M |
| | Doors and Windows — Installation Only | Alfreton | £60M |
| | Gloucester Kings Quarter Phase 2 | Gloucester | £60M |
| | Tower & Ashbourne Construction | Berkshire | £60M |
| | Bitumen and Associated Products | Paisley | £56M |
| | Medicines Discovery Catapult Limited | London | £54M |
| | Vaccination Helpline - Call Handling | Leeds | £54M |
| | Test Digital Platform | Leeds | £51M |
| | Highways Maintenance, Improvements, and Street Lighting | Sutton | £50M |
| | Office Buildings - Planned and Reactive Maintenance | London | £50M |
| | Pre- Market Engagement Event and Questionnaire for the Construction of 193 Homes at Tower and Ashbourne… | Berkshire | £50M |
| | Additional Supplier of Concrete Sleepers | London | £49M |
| | Covid 19 Vaccinations Programme - Workforce Delivery | Leeds | £48M |
| | Residual Waste Disposal | Chelmsford | £45M |
| | Essex Community Wellbeing Service | Chelmsford | £45M |
| | Residual Waste Disposal | Bournemouth | £40M |
| | Combined Safety Syringes and Needles for the COVID-19 Vaccination Programme | Normanton | £39M |
| | Railway Systems - Cross-Passage Doors | Birmingham | £36M |
| | Camden Highline: A New Public Park and Garden Walk, Transforming the Elevated Railway Between Camden Town… | London | £35M |
| | HPFT, HCT — Soft Facilities Management | Hatfield | £35M |
| | Total Facilities Management | London | £35M |
| | Tower 2 - Surgical Mesh, Fixation Devices, Stress Incontinence and Bulking Agents | London | £35M |
| | Mansfield District Council Leisure Operating | Nottingham | £33M |
| | Community Endoscopy Services to Oxfordshire Clinical Commissioning Group | Oxford | £31M |
| | Alliance Agreement for Support Services for Drug & Alcohol Treatment, Domestic Abuse and the Homeless Hostel… | Torquay | £31M |
| | Geospatial Data Services | Southampton | £30M |
| | GMCA 267a GM One Network | Salford | £30M |
| | T842 Understanding Society W13-15 | Colchester | £30M |
| | T842 Understanding Society 2020 To | Colchester | £28M |
| | Radiology Reporting Services | Edinburgh | £28M |
| | Freshly Prepared Sandwiches, Wraps, Paninis and Salads | Coventry | £26M |
| | Contact Management Solution | Carmarthen | £25M |
| | Integrated Community Equipment Services | Sandbach | £25M |
| | Maintenance and Testing of Fire Alarm Systems [3413748] | Ballymena | £25M |
| | Endoscopy Services to Oxfordshire Clinical Commissioning Group | Oxford | £25M |
| | Rotherham Sexual Health Services - All Ages | Rotherham | £25M |
| | NRW Next Generation Construction Services 2020 | Cardiff | £24M |
| | Substance Misuse Treatment Services (Leicestershire and Rutland) | Leicester | £24M |
| | ARP Field Services | London | £24M |
| | Core Community Drug and Alcohol Services — Lot 1 Substance Misuse Treatment Service | London | £23M |
| | Framework for Stair Lifts, Access Lifts, Track Hoist Systems and Slings - Incl Supply,Delivery, Installation, Removal,… | Glasgow | £23M |
| | East Lothian Kerbside Waste Collection | East Lothian | £23M |
| | Covid 19 Vaccinations Programme: Programme Resources | Leeds | £20M |
| | Asbestos ACM Removals and Associated Services and Associated Works | Yeovil | £20M |
| | Civil Engineering Enabling Works at Holborn, South Shields - To Include Extensive Maritime and Geotechnical Elements… | South Shields | £20M |
| | External Wall Systems (EWS) Surveying, Inspection & Reporting Requirements Framework | London | £20M |
| | HPFT, HCT — Hard Facilities Management | Hatfield | £20M |
| | Energy Efficiency Measures Under the Green Homes Grant Local Authority Delivery Scheme | Ealing | £19M |
| | Catering Services | Kettering | £19M |
| | Call Off the Construction of Multi-Storey Car Park, Gateshead Under Scape Procure National Construction Framework Lot… | Gateshead | £19M |
| | NHS Scotland National Uniform | Edinburgh | £19M |
| | Project Hire of Specialist Trailers | London | £19M |
| | Yorkshire Housing Association - Moor Lane, Menston - New Build | Preston | £18M |
| | Onboard Laundry Service to Major Royal Navy Surface Warships | Portsmouth | £17M |
| | Prior Information Notice: Design, Develop, and Demonstrate Wave Energy Converter Systems (EuropeWave PCP) | Inverness | £16M |
| | Adult Male and Female; Acute, PICU and Rehabilitation Inpatient Bed | Birmingham | £16M |
| | WSCC - TH - Woodlands Meed College Construction MC2 | West Sussex | £15M |
| | Consortium Academy Trust | East Yorkshire | £15M |
| | Clinical Digital Professional Services (CDPS) Framework Agreement | London | £15M |
| | HPFT, HCT — Catering Services | Hatfield | £15M |
| | NHSX: Digital Social Care Record Systems - DPS | London | £15M |