| | Hampshire Accommodation Development and Support Options Model Open Framework (HADSOM) | Winchester | £1B |
| | Greater South East Energy Hub Trades DPS | Ely | £1B |
| | Medium Schemes Framework 4 (MSF4) on Behalf of Midlands Highways Alliance Plus (MHA+) | Leicester | £1B |
| | Sustainable Housing Development Framework | Oxford | £1B |
| | SARS-CoV-2 Antigen Rapid Qualitative Test Kits | London | £728M |
| | Overseas Capital Framework | Glasgow | £560M |
| | Manufacture of Lateral Flow Antigen Tests for SARS-CoV-2 | London | £503M |
| | WSCC SB Supported Living Framework | Chichester | £365M |
| | Armed Forces Pay, Pensions and Military HR and Administrative Services | London | £294M |
| | Operational, Management and Maintenance Services at Brook House Immigration Removal Centre and Tinsley House Immigration Removal… | London | £277M |
| | Washwood Heath Depot & Network Integrated Control Centre for HS2 Limited | Birmingham | £275M |
| | Washwood Heath Railway Systems Maintenance Depot (WWH) & Network Integrated Control Centre (NICC) for HS2 Phase… | Birmingham | £275M |
| | Artificial Limb Components and Associated Products | Sheffield | £240M |
| | Liquid Fuels | Newcastle upon Tyne | £160M |
| | South East & Mid Wales Highways & Civil Engineering Framework | Cardiff | £160M |
| | NTP Deloitte Support Phases 3 & 4 | London | £145M |
| | Hard Facilities Management Services | Cambuslang | £135M |
| | Mobile Client Device Framework | Glasgow | £125M |
| | Cytokine Modulators | Edinburgh | £116M |
| | Personal Protective Equipment (PPE) | Liverpool | £106M |
| | Automated Laboratory Medicine Systems | Londonderry | £105M |
| | Heavy and Municipal Vehicles | Paisley | £100M |
| | Materials) | Bolton | £100M |
| | Microsoft Cloud Solution Provider | West Malling | £100M |
| | Network Reseller Services | West Malling | £100M |
| | Repairs and Maintenance Services | Bolton | £100M |
| | Specialist Personal Protective Equipment (PPE) | Maidstone | £100M |
| | Security Guarding Services for the BE in Mexico City | London | £94M |
| | Outdoor Playground, Fitness & Sports Facilities and Equipment (Design, Supply, Delivery, Installation, Maintenance and Inspection) | Leicester | £86M |
| | DPS for Domiciliary Care Services in Powys | Llandrindod Wells | £86M |
| | Adult Secondary Mental Health Services in West Essex | Epping | £80M |
| | Outdoor Playground, Fitness & Sports Facilities and Equipment (Design, Supply, Delivery, Installation, Maintenance and Inspection) | Leicester | £80M |
| | Consultancy Services Framework | Surrey | £70M |
| | Additional Call Centre Capacity | Edinburgh | £60M |
| | Managed Operated Service and Self-Drive Plant Hire Services | Glasgow | £60M |
| | Vehicle and Plant Hire | Paisley | £60M |
| | Compounded Monoclonal Antibodies | Bracknell | £54M |
| | Test Digital Platform | Leeds | £51M |
| | PNC Mainframe Support and Maintenance | London | £48M |
| | Bitumen and Associated Products | Paisley | £45M |
| | AWS_HMRC004 - Compute | London | £41M |
| | Care at Home (Lancashire & South Cumbria) - Domiciliary Care | Milton Keynes | £40M |
| | Parliamentary Travel Office | London | £38M |
| | Logistics Movement Support Services for British Forces Cyprus and Sovereign Base Area | Episkopi | £38M |
| | Antidotes and Antibiotics | Runcorn | £35M |
| | Antidotes and Antibotics | London | £35M |
| | Barne Barton, Plymouth | Worcester | £35M |
| | HPFT, HCT - Soft Facilities Management | Hatfield | £35M |
| | Defence Virtual Simulation 2 (DVS2) | Bristol | £30M |
| | Tyres for Vehicles and Plant | Paisley | £26M |
| | Future Schools Network Service for Educational Establishments in Hampshire and Southampton | Winchester | £25M |
| | Information Management Systems 4 (IMS4) | London | £25M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £24M |
| | Improving Access to Psychological Therapies (IAPT) Services for West Essex | Epping | £22M |
| | Training and Support to Young People (16-19) Through Partner Organisations | Truro | £21M |
| | HPFT, HCT - Hard Facilities Management | Hatfield | £20M |
| | HPM Multi Trade SME Local Sub Contractor Services Framework | London | £20M |
| | Northamptonshire County Council Brighter Futures Commissioning and Framework | Northampton | £20M |
| | Parks and Leisure Services | London | £20M |
| | Radiology Reporting Services | Edinburgh | £20M |
| | Traffic Signal Equipment - Framework 2021 | Leeds | £20M |
| | Periodic Servicing, Responsive Maintenance and Renewal of Gas Domestic Appliances | London | £19M |
| | Warehouse Services - Bardon 22 | London | £19M |
| | NHS National Generic Pharmaceuticals Interim 2 | Runcorn | £19M |
| | Translation and Interpretation Services | Liverpool | £19M |
| | Construction Framework | East Lothian | £18M |
| | Family Centres in Swansea | Swansea | £18M |
| | CM88a TSC for Gas and Solid Fuel Servicing, Repairs, Call Out and Central Heating Installation | Beverley | £17M |
| | Gas and Solid Fuel Servicing, Repairs, Call-Out and Central Heating Installation | Beverley | £17M |
| | T Levels Wave 3 - Lot 2 Legal, Finance and Accounting: Finance/ Lot 3 Legal, Finance… | London | £16M |
| | Christmas Illuminated Forest Trail Event | Bristol | £15M |
| | Tendring District Council Responsive Maintenance, Out of Hours Emergency Works, Void Property Works and Major Works… | Clacton on Sea | £15M |
| | Hair, Beauty and Wigs Supplies | Salford | £15M |
| | High Integrity Stainless Steel | Seascale | £15M |
| | HPFT, HCT - Catering Services | Hatfield | £15M |
| | International Student Pathway Services | Southampton | £15M |
| | Get Help With Technology - Spot Buy | London | £14M |
| | General Practice Patient Survey (GPPS) | Runcorn | £14M |
| | Collection and Treatment of Residual Waste | Llandrindod Wells | £14M |
| | Establishment of a New Regional Body (Sport North Wales) | Cardiff | £14M |
| | Apprenticeship Training Services | Salford Quays | £14M |
| | Managed Print Services | Swansea | £13M |
| | Pitched Roofing Replacement and Associated Works | Birmingham | £13M |
| | Chain Transformation Expansion, Warehousing and Distribution Optimisation (WDO) Industry Day | Bristol | £12M |
| | Watford Business Park Development | Watford | £12M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £10M |
| | A1/Queen Margaret University Junction Construction Works | East Lothian | £10M |
| | Collaborative Robots (COBOTS) | Hampshire | £10M |
| | Development of Former Swimming Pool Site, Sansome Walk , Worcester | Worcester | £10M |
| | Development of Former Swimming Pool Site, Sansome Walk, Worcester | Worcester | £10M |
| | ICT Goods and Services | Walsall | £10M |
| | International Student Pathway Services | Southampton | £10M |
| | Investment and Refurbishment Works in Dumfries and Galloway Area | Glasgow | £10M |
| | BHCC MH Supported Accommodation for Young People | Hove | £10M |
| | Fit Testing Team for NHS FFP3 Masks | London | £9M |
| | Forest Plants to NRW – Long Term | Cardiff | £9M |
| | London Luton DART Facilities Management and Passenger Services | Luton | £9M |
| | National Fit Test Team Extension | London | £9M |
| | Service Contract | London | £9M |
| | Soha Repair | Didcot | £9M |