| | NHS Increasing Capacity Framework | Leeds | £10B |
| | Multi Specialism Services Frameworks | Penicuik | £6B |
| | Digital Outcomes and Specialists 5 | Liverpool | £2B |
| | Sustainable Housing Development Framework | Oxford | £1B |
| | Digital Capability for Health | Liverpool | £800M |
| | Publication of Redacted Contracts | Blackpool | £746M |
| | SARS-CoV-2 Antigen Rapid Qualitative Test Kits | London | £722M |
| | Scape National Consultancy Framework | Nottingham | £700M |
| | Publication of Redacted Contracts | Blackpool | £607M |
| | Manufacture of Lateral Flow Antigen Tests for SARS-CoV-2 | London | £503M |
| | Facilities Management Services | Leicester | £500M |
| | Temporary Agency Workers for Northern Ireland Civil Service, Agencies and Non Departmental Public Bodies | Belfast | £425M |
| | Refurbishment Works Framework Agreement | London | £400M |
| | Publication of Retracted Contracts | Blackpool | £349M |
| | Grand Union Housing Electricity and Gas Procurement Framework | Milton Keynes | £300M |
| | Able Marine Energy Park - Main Quay Works | St Helier | £285M |
| | Specialist Bridges Inspection and Maintenance | Bristol | £240M |
| | Tyres, Glass and Fast Fit Solutions | Liverpool | £200M |
| | Professional Services Framework | Edinburgh | £150M |
| | Phase 3 Early Learning and Childcare - South Lanarkshire Council Procured Service Arrangement | Hamilton | £144M |
| | National for Waste Management and Minimisation | Chester | £136M |
| | LTE Vehicle Devices and Accessories for the Emergency Services Network (ESN) | London | £130M |
| | All Wales Orthopaedic, Trauma and Joint Replacement Framework | St Asaph | £125M |
| | Daytime Activities Provider List | Bradford | £119M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £117M |
| | Cytokine Modulators | Edinburgh | £116M |
| | Trade Law Panel | Liverpool | £115M |
| | Mental Health Services Across Wigan Borough | Wigan | £114M |
| | Domiciliary Care Lead Patch Provider Framework | Bromley | £110M |
| | DoF - Digital NI - Contact Centre Services for Government | Belfast | £100M |
| | Microsoft Cloud Solution Provider | West Malling | £100M |
| | Network Reseller Services | West Malling | £100M |
| | Strategic Client Friend (SCF) Support Arrangement | Bristol | £100M |
| | Mechanical Handling and Lifting - Material Supply and Repair | Bristol | £98M |
| | Site at Liddell Road, NW6 | London | £80M |
| | Consultancy Services Framework | Surrey | £70M |
| | Community Services in Brent and Harrow | Wembley | £58M |
| | North Devon Link Road | Exeter | £55M |
| | West Sussex Gigabit | West Sussex | £53M |
| | Critical Communications Infrastructure Framework | West Yorkshire | £50M |
| | Refurbishment Works Framework Agreement | London | £50M |
| | NHS National Generic Pharmaceuticals Interim 2 | Runcorn | £49M |
| | Dermatology Services | Cambridge | £48M |
| | Support at Home | Hengoed | £47M |
| | Text Books, Pupil Workbooks, Assessment Resources and Music Materials | Ballymena | £40M |
| | Laboratory Testing Services | London | £38M |
| | Logistics Movement Support Services for British Forces Cyprus and Sovereign Base Area | Episkopi | £38M |
| | PSCP - DPOW Grimsby and Scunthorpe General Hospital AAU/ED Schemes | Grimsby | £37M |
| | Flexible Framework for Early Learning and Childcare Services in North Lanarkshire 2020/2023 — Entry Point 2… | Motherwell | £36M |
| | Housing Delivery Framework | Ashford | £36M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £35M |
| | Non-Emergency Patient Transport - NHS Shropshire CCG and NHS Telford Wrekin CCG | Stoke on Trent | £33M |
| | Non-Emergency Patient Transport Services for NHS Shropshire CCG, NHS Telford and Wrekin CCG and Powys Teaching… | Telford | £33M |
| | Oils, Lubricants, Greases, and Additives | Bristol | £33M |
| | IRLA - Antibodies and Sera (And Other Matrices) | Reading | £32M |
| | IRLA - Antibodies and Sera (And Other Matrices) Framework (1) | Reading | £32M |
| | Receipt, Bulking, Haulage, and Treatment of Food Waste and Green Garden Waste | Kingston upon Thames | £32M |
| | Defence Virtual Simulation 2 (DVS2) | Bristol | £30M |
| | Future Life Jackets, Buoyancy Aids and Floatation Devices | Bristol | £30M |
| | Laboratory Consumables and Reagents | Birmingham | £30M |
| | Uniforms and Workwear for Emergency Services | Wakefield | £30M |
| | Oncology Generics Medicines | Edinburgh | £29M |
| | Council Housing Electrical Upgrade Programme Phase 2 | Sheffield | £27M |
| | Services for the Transfer, Management and Treatment of Green, Food, Bulky and Wood Waste | Aylesbury | £27M |
| | Roofing Works | Liverpool | £26M |
| | Bulk Waste Haulage Services | Chelmsford | £26M |
| | Post Office Banking Automation | London | £26M |
| | Thrombotic Thrombocytopenic Purpura (TTP) | London | £26M |
| | Integrated Healthcare Services for HMP Onley & an Integrated Substance Misuse Service for HMP Rye Hill… | Mansfield | £25M |
| | Tocilizumab Subcutaneous Injection (RoActemra®) | Edinburgh | £25M |
| | Streetlighting and Traffic Signals Electricity Supply | Blackpool | £25M |
| | Workplace Uniforms | Birmingham | £25M |
| | PET Scanning Service for SE Wales | Pontypridd | £24M |
| | SCF Lot 2 Mini-Competition: Princes Parade Leisure Centre Design & Build | Folkestone | £23M |
| | Weight Management Services - Obesity Framework | Leeds | £23M |
| | Winterstoke Hundred Academy Expansion Design & Build | Weston Super Mare | £23M |
| | General Building Works | Bath | £20M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £20M |
| | Procurement Hub Furniture and Furnishings Framework | Preston | £20M |
| | North Fife School Buses | Glenrothes | £20M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £20M |
| | Non-Emergency Patient Transport Service 13.185b2 | Lewes | £19M |
| | Leadership Management Development | London | £18M |
| | Lifts, Escalators and Related Equipment Maintenance, Repairs and Refurbishment | Durham | £18M |
| | Vehicle Conversions | Edinburgh | £17M |
| | Jobs for Economic Transformation Programme Ghana (JET) | East Kilbride | £16M |
| | EPOS Systems | Manchester | £16M |
| | AHDB Technical Framework Agreement | Kenilworth | £15M |
| | Finance Support Delivery Partner | Bristol | £15M |
| | Northern Ireland Fire and Rescue Service - Term Service Contracts | Lisburn | £15M |
| | Post Design, Technical Support and Development of the VCCI Toolset | Bristol | £15M |
| | Building Maintenance and Repairs to Humberside Police | Sheffield | £15M |
| | Metering Contract | Durrington | £15M |
| | Young People's Supported Accommodation Pathway | London | £14M |
| | Young People’s Supported Accommodation Pathway | London | £14M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £14M |
| | Work and Health Programme Job Entry: Targeted Support (JETS) Sub | Trowbridge | £14M |
| | Look Ahead Care and Support Repairs & Voids | London | £13M |
| | Central Foundation Boys' School — Phase 2 | London | £13M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £13M |